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Order Stromectol over the counter consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Stromectol is an injectable parasiticide for cattle and swine. One low-volume dose effectively treats and controls the following internal and external parasites that may impair the health of cattle and swine: gastrointestinal roundworms (including inhibited Ostertagia ostertagi in cattle), lungworms, grubs, sucking lice, and mange mites of cattle; and gastrointestinal roundworms, lungworms, lice, and mange mites of swine. Ivermectin is derived from the avermectins, a family of potent, broad-spectrum antiparasitic agents isolated from fermentation of Streptomyces avermitilis. IVERMECTIN Injection is a clear, ready-to-use, sterile solution containing 1% ivermectin, 40% glycerol formal, and propylene glycol, q.s. 100%. Stromectol Injection is formulated to deliver the recommended dose level of 200 mcg Stromectol/kilogram of body weight in cattle when given subcutaneously at the rate of 1 mL/110 lb (50 kg). In Swine, IVERMECTIN Injection is formulated to deliver the recommended dose level of 300 mcg ivermectin/kilogram body weight when given subcutaneously in the neck at the rate of 1 mL per 75 lb (33 kg).
Stromectol bindet an eine hohe Affinität für regulierte Gamma-Aminobuttersäure (GABA) und Glutamat (GluCl) an Chloridkanäle in den Nerven- und Muskelzellen von wirbellosen Tieren und verursacht Lähmungen und den Tod des Parasiten.
Dogs testing positive for heartworms should be observed closely for at least eight hours following the administration of Stromectol. Neurotoxicity can also occur with Stromectol usage in some dogs. This is particularly common in dogs that have a genetic mutation known as the MDR1 (multiple drug resistance) gene mutation. This gene mutation is known to occur most commonly in breeds such as Collies, Australian shepherds, Shelties, Long-haired whippets, English sheepdogs, German shepherds, Silken Windhounds, Skye terriers, and other breeds with white feet. Symptoms of neurotoxicity include lack of coordination, muscle tremors, seizures, blindness, and death, thus giving rise to the motto "white feet, do not treat" with ivermectin. Ivermectin, used at dosages for heartworm prevention, is generally safe for these dogs. However, the drug should not be used at higher doses for dogs that may possess the MDR1 gene mutation. There is a test that can be performed to check for this gene mutation. Ask your vet for more advice. Ivermectin toxicity is very serious and it cannot be reversed. Speak to your vet right away if you believe your pet is suffering from an adverse reaction. They may recommend inducing vomiting or administering charcoal to minimize absorption of the drug. In addition to its use in veterinary medicine, ivermectin is also used by doctors to treat a number of health issues in people. In humans, it is also useful in eliminating parasites. Ivermectin can be used to treat head lice, scabies, river blindness, and other conditions. It is only available with a prescription and is usually applied topically or taken orally. Keep in mind that no medication specifically labeled for animal use should be taken by humans. Presently, there is no reliable evidence to suggest the efficacy or safety of ivermectin against SARS-CoV-2, the virus that causes COVID-19, in humans.
Stromectol is active against most nematode parasites. It can also be used in the treatment of arthropod ectoparasite infestations such as scabies. Its principal indications are for treatment of onchocerciasis and strongyloidiasis. Additionally, it shows useful activity against a number of other helminth parasites, particularly Ascaris lumbricoides. Stromectol causes an influx of Cl- ions through the cell membrane of invertebrates by activation of specific ivermectin-sensitive ion channels. The resultant hyperpolarization leads to muscle paralysis. Widespread use of ivermectin for treatment of intestinal nematode infections of sheep and goats has led to the development of drug resistance in veterinary practice. Reports have emerged from West Africa pointing to a reduced effect of ivermectin in onchocerciasis. Resistance may be associated with alterations in P-glycoprotein gene expression. Stromectol is rapidly absorbed with .Cmax is proportional to dose, with a value of approximately 38-46 µg/L reached after a therapeutic dose of 150-200 µg/kg. Estimates of the terminal half-life of the parent drug range from 28-56 hours. Ivermectin is generally administered as a single dose of 150-200 µg/kg. In the absence of parasitic infection, the adverse effects of ivermectin in therapeutic doses are minimal. Adverse effects seen in filarial infections include fever, myalgia, malaise, lightheadedness, and occasionally postural hypotension. In onchocerciasis, skin oedema, pruritis and mild eye irritation may be seen.